Igipande co hanze c’ibiherere ku mubiri n’imigera, citwa “extracellular matrix” canke ECM, gifise uburyo bumwe nk’ubw’umunyu w’ibitoke kandi gikora nk’igipande co gukingira n’igikoko. Ariko nk’uko bigaragara mu bushakashatsi bwakozwe vuba aha mu kinyamakuru iScience, bwakozwe na Kaminuza ya Massachusetts Amherst ifatanije n’Ikigo ca Worcester Polytechnic Institute, ECM y’imigera imwimwe igira gel gusa iyo hariho aside oxalique canke izindi aside zoroheje. Kubera ko ECM ifise uruhara runini muri vyose kuva ku guhangana n’imiti igabanya ubukana bw’indwara gushika ku mirongo y’amazi ipfutse no kwanduza ibikoresho vy’ubuvuzi, gutahura ingene imigera ikoresha ibice vyayo vy’amazi bifatanye, biragira ico bikoze cane ku buzima bwacu bwa misi yose.

Barry Goodell, umwigisha w’ivy’imigera muri Kaminuza ya Massachusetts Amherst akaba n’umwanditsi mukuru w’ico kinyamakuru, yavuze ati: “Nama nkunda cane ivy’imigera yitwa ECMs. "Abantu kenshi biyumvira ko ECM ari ikintu co hanze kirinda imigera. Ariko kandi, irashobora gukora nk'umuyoboro w'ingaburo n'intungamubiri zija no kuva mu ngingo z'imigera."
Ico gipfukisho gifise ibikorwa vyinshi: ukuntu gifatanye bisigura ko imigera imwe imwe ishobora kwifatanya kugira ngo ikore amakoloni canke “ibinyabuzima”, kandi iyo imigera ihagije ibikoze, irashobora gufunga imiyoboro canke igahumanya ibikoresho vyo mu buvuzi.
Ariko kandi, igikoko gitegerezwa kuba gishobora guca mu mubiri: imigera myinshi isohora enzymes zitandukanye n’ibindi bihimba bihindura ibiribwa hanze biciye mu ECM, bikaja mu bintu bishaka kurya canke kwanduza (nk’ibiti biboze canke ibihimba vy’ibikoko bifise urutirigongoye), hanyuma, iyo enzymes zimaze kurangiza igikorwa cazo, igikorwa co gufata ibiribwa – zigasubiza ingaburo biciye mu ECM.
Ivyo bisigura ko ECM atari gusa igice c’uburinzi kidakora; Nkako, nk’uko Goodell na bagenzi biwe babigaragaje, imigera isa n’iyifise ubushobozi bwo kugenzura ukuntu ECM yayo ikora neza, bigatuma rero ishobora guca mu mazi. None babigira gute?
Mu biherere ku mubiri, ivyo biva mu bihimba vy’umubiri bisa n’uko ari aside oxalique, aside isanzwe iboneka mu bimera vyinshi, kandi nk’uko Goodell na bagenzi biwe babibonye, ​​imigera myinshi isa n’ikoresha iyo aside oxalique isohoka kugira ngo ifatanye n’ibice vyo hanze vy’ibifungurwa birimwo ibinure. guhingura ikintu kifatanye. , ECM imeze nk’iyitwa jeli.
Ariko iyo ntumwa imaze kwihweza neza, basanze aside oxalique idafasha gusa mu guhingura ECM, ariko kandi “iyitunganya”: uko imigera yongera aside oxalique ku ruvange rw’ibifungurwa birimwo ibinure n’aside, ni ko ECM irushiriza gukomera. Uko ECM igenda irakomera, ni ko ibuza utugingo ngengabuzima tunini kwinjira canke kuva muri iyo mikorobe, mu gihe utugingo ngengabuzima dutoduto tuguma twidegemvya kugira ngo twinjire muri iyo mikorobe tuvuye mu bidukikije be n’ibihushanye n’ivyo.
Ivyo bintu vyavumbuwe biratera ingorane ugutahura kwa kera kw’abahinga ku bijanye n’ingene ubwoko butandukanye bw’ibintu biva mu biherere ku mubiri be n’imigera mu vy’ukuri biva muri ivyo bikoko bitobito bikaja mu bidukikije. Goodell na bagenzi biwe bavuze yuko mu bihe bimwebimwe imigera yoshobora gutegerezwa kwizigira cane ukuntu utugingo ngengabuzima dutoduto cane dusohoka kugira ngo itere umubiri canke umubiri uwo mugera wizigira kugira ngo ushobore kubaho canke ngo ushobore kwanduzwa. Ivyo bisigura ko ugusohoka kw’utugingo ngengabuzima dutoduto na kwo nyene gushobora kugira uruhara runini mu gutera indwara iyo enzymes nini zidashobora guca mu nzira y’imigera y’inyuma y’ingingo ngenderwako.
Goodell yavuze ati: “Bisa n’uko hariho ikibanza co hagati, aho imigera ishobora kugenzura urugero rw’aside kugira ngo imenyere ibidukikije bimwebimwe, igakomeza kugumya bimwe mu bihimba bininibinini, nk’intungamubiri zitwa enzymes, mu gihe ireka utugingo ngengabuzima dutoduto tugaca muri ECM bitagoranye. antibiyotike, kubera ko myinshi muri iyo miti igizwe n’ibihimba binini cane. Ubwo bushobozi bwo guhindura ibintu ni bwo bushobora kuba urufunguruzo rwo gutsinda imwe mu nzitizi zikomeye mu buvuzi bw’imigera, kuko gukoresha ECM kugira ngo ishobore guca mu mubiri bishobora gutuma imiti irwanya imigera n’imigera irwanya imigera ikora neza.

Goodell ati: “Nimba dushobora kugenzura ubuhinga bwo gukora ibinyabuzima (biosynthèse) n’ugusohoka kw’utugingo ngengabuzima dutoduto nka oxalate mu migera imwimwe, rero twoshobora no kugenzura ivyo bishika muri iyo mikorobe, ivyo bikaba vyoshobora kudufasha kuvura neza indwara nyinshi ziterwa n’imigera.”
Mu kwezi kwa kigarama 2022, umuhinga mu vy'imigera yitwa Yasu Morita yararonse ingurane ivuye mu kigo c'igihugu c'ubuzima kugira ngo ashigikire ubushakashatsi buzoheza bugamije gutegura uburyo bushasha kandi bukora neza bwo kuvura igituntu.

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